Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease with symptoms that go beyond the domain of glucose metabolism. In fact, research has shown that T2DM is accompanied by neurodegeneration and neuroinflammation. Interestingly, Major Depressive Disorder (MDD), a mood disorder characterized mainly by depressed mood and anhedonia is a key feature of T2DM. A body of evidence demonstrates that there are many shared neuroimmune mechanisms underlying the pathophysiology of T2DM and MDD. Therefore, here we review the state-of-art regarding the underlying factors common to both T2DM and MDD. Furthermore, we briefly discuss how depressive symptoms in diabetic patients could be tackled by using novel therapeutic approaches uncovered by these shared mechanisms. Understanding the comorbidity of depression in diabetic patients is essential to fully address T2DM pathophysiology and treatment.

2 型糖尿病 (T2DM) 是一种慢性代谢疾病，其症状超出了葡萄糖代谢的范畴。事实上，研究表明 T2DM 伴有神经退行性变和神经炎症。有趣的是，重度抑郁症 (MDD) 是一种主要以抑郁情绪和快感缺乏为特征的情绪障碍，是 T2DM 的一个关键特征。大量证据表明，T2DM 和 MDD 的病理生理学存在许多共同的神经免疫机制。因此，在这里，我们回顾了有关 T2DM 和 MDD 共同潜在因素的最新技术。此外，我们简要讨论了如何通过使用这些共享机制所揭示的新治疗方法来解决糖尿病患者的抑郁症状。