Long term regular intake of black tea (BT) can lower blood pressure, which is probably due to its antioxidant activity and angiotensin converting enzymes (ACE) inhibitory activity. This study achieves a comprehensive understanding of the relationship between bioactive compounds of BT and its ACE inhibitory activity and antioxidant activity. Phenolic compounds are closely related to antioxidant activity and ACE inhibitory activity. Catechin (C) exhibits stronger inhibitory activity on ACE enzyme than that of other compounds. Molecular docking demonstrates that C could directly bind to ACE active site pockets and Zn(II). Other bioactive compounds are involved in antioxidant and ACE inhibitory activity in varying degrees but no obvious trend is established. Our study proposes a conjecture that some bioactive compounds of BT regulate antioxidant defenses through mechanisms that involve ACE. The mixed mode of in vitro inhibition of ACE and oxidant of BT bioactive compounds needs to be further investigated.

长期定期摄入红茶（BT）可以降低血压，这可能是由于其抗氧化活性和血管紧张素转换酶（ACE）抑制活性所致。这项研究全面了解了BT的生物活性化合物与其ACE抑制活性和抗氧化活性之间的关系。酚类化合物与抗氧化剂活性和ACE抑制活性密切相关。儿茶素（C）对ACE酶的抑制作用比其他化合物强。分子对接表明，C可以直接与ACE活性位点口袋和Zn（II）结合。其他生物活性化合物在不同程度上参与抗氧化剂和ACE的抑制活性，但没有明显的趋势。我们的研究提出了一个推测，即一些生物活性的BT化合物通过涉及ACE的机制来调节抗氧化防御。的混合模式ACE的体外抑制作用和BT生物活性化合物的氧化剂有待进一步研究。