Stem cells can be used to repair dysfunctional and injured (or cancerous) tissues by delivering therapeutics. However, in comparison with other cells, it is harder to transfect drugs or genes into stem cells. Dendrimers have been considered as efficient vectors to deliver both genes and drugs to stem cells due to their unique properties including adjustable molecular weight and size, low toxicity, high loading capacity, and having multiple peripheral chemical agents which can be functionalized to improve deliverance efficiency. In this review, we discuss dendrimer-mediated drug and gene delivery to stem cells as cellular vehicles and the role of this strategy in treating a variety of disorders via regenerative medicine approaches.

中文翻译：

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树枝状大分子作为细胞载体将药物和基因靶向递送至干细胞的最新进展

干细胞可用于通过提供治疗来修复功能失调和受伤（或癌变）的组织。然而，与其他细胞相比，将药物或基因转入干细胞更难。树枝状大分子被认为是向干细胞递送基因和药物的有效载体，因为它们具有独特的特性，包括可调节的分子量和大小、低毒性、高负载能力，以及具有多种可以被功能化以提高递送效率的外围化学试剂。在这篇综述中，我们讨论了树枝状大分子介导的药物和基因作为细胞载体向干细胞的传递，以及这种策略在通过再生医学方法治疗各种疾病中的作用。