Circ_0137287 was found to be decreased in papillary thyroid cancer (PTC) tissues and related to aggressive clinicopathologic characteristics. However, the role and mechanism of circ_0137287 in PTC remain vague. Circ_0137287 expression was decreased in PTC and its low expression predicted poor survival. The ROC analysis suggested circ_0137287 might be a marker for PTC diagnosis. Circ_0137287 overexpression in PTC cells impaired cell proliferation, migration, invasion, and aerobic glycolysis, but induced apoptosis in vitro and in vivo. Circ_0137287 specifically bound to miR-183-5p, and miR-183-5p reversed the inhibitory effects of circ_0137287 on PTC tumor growth, motility and aerobic glycolysis. MiR-183-5p directly targeted PPP2R2A, and promoted PTC progression through regulating PPP2R2A. Mechanistically, circ_0137287 could indirectly modulate PPP2R2A expression through targeting miR-183-5p. Circ_0137287 suppressed PTC tumorigenesis and aerobic glycolysis through up-regulating PPP2R2A via miR-183-5p absorption, indicating a promising prognostic, diagnostic and therapeutic target.

发现 Circ_0137287 在甲状腺乳头状癌 (PTC) 组织中减少，并且与侵袭性临床病理学特征有关。然而，circ_0137287在PTC中的作用和机制仍不清楚。Circ_0137287 在 PTC 中的表达降低，其低表达预示着较差的存活率。ROC 分析表明 circ_0137287 可能是 PTC 诊断的标志物。PTC 细胞中的 Circ_0137287 过表达会损害细胞增殖、迁移、侵袭和有氧糖酵解，但在体外和体内诱导细胞凋亡。Circ_0137287 与 miR-183-5p 特异性结合，miR-183-5p 逆转了 circ_0137287 对 PTC 肿瘤生长、运动和有氧糖酵解的抑制作用。MiR-183-5p直接靶向PPP2R2A，通过调控PPP2R2A促进PTC进展。机械地，circ_0137287 可以通过靶向 miR-183-5p 间接调节 PPP2R2A 的表达。Circ_0137287 通过 miR-183-5p 吸收上调 PPP2R2A 来抑制 PTC 肿瘤发生和有氧糖酵解，表明它是一个有前景的预后、诊断和治疗靶点。