We present a quantitative model to provide robust estimation of the decorrelation time using laser speckle auto-inverse covariance. It has the advantages of independence from the statistical sample size, speckle size, static scattering, and detector noise. We have shown cerebral blood flow imaging through an intact mouse skull using this model. Phantom experiments and two animal models, middle cerebral artery occlusion, and cortical spreading depression were used to evaluate its performance.

中文翻译：

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用于可靠估计血流的定量激光散斑自逆协方差成像

我们提出了一个定量模型，以使用激光散斑自逆协方差对去相关时间进行稳健估计。它具有独立于统计样本大小、散斑大小、静态散射和检测器噪声的优点。我们已经使用该模型通过完整的小鼠头骨展示了脑血流成像。使用体模实验和大脑中动脉闭塞、皮质扩散抑制两种动物模型对其性能进行评价。