Cancer and malaria both have high incidence rates and are leading causes of mortality worldwide, especially in low and middle-income countries with reduced access to the quality healthcare. The objective of this critical review was to summarize key associations and new perspectives between the two diseases as is reported in existing literature. A critical review of research articles published between 1st January 2000 – 1st July 2020 which yielded 1753 articles. These articles were screened based on a precise inclusion criteria. Eighty-nine eligible articles were identified and further evaluated. Many articles reported anti-cancer activities of anti-malarial medicines, including Artemisinin and its derivatives. Other articles investigated the use of chemotherapy in areas burdened by malaria, treatment complications that malaria may cause for cancer patients as well as ways to circumvent cancer related drug resistance. Potential novel targets for cancer treatment, were identified namely oncofoetal chondroitin sulphate and haem, as well as the use of circumsporozoite proteins. A number of articles also discussed Burkitt lymphoma or febrile neutropenia. Overall, excluding for Burkitt lymphoma, the relationship between cancer and malaria requires further extensive research in order to define association. There great potential promising new novel anti-cancer therapies using anti-malarial drugs. Created using BioRender

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疟疾和癌症：对已建立的协会和新观点的批判性评论

癌症和疟疾都具有很高的发病率，并且是导致世界范围内死亡的主要原因，尤其是在获得优质医疗保健机会较少的中低收入国家中。这项重要评论的目的是总结现有文献中所报道的两种疾病之间的关键关联和新观点。对2000年1月1日至2020年7月1日之间发表的研究文章进行的严格审查，产生了1753篇文章。这些文章是根据精确的纳入标准筛选的。确定了89篇合格文章，并进行了进一步评估。许多文章报道了抗疟疾药物（包括青蒿素及其衍生物）的抗癌活性。其他文章调查了在疟疾负担较重的地区使用化学疗法的情况，疟疾可能对癌症患者造成的治疗并发症，以及规避癌症相关耐药性的方法。确定了潜在的癌症治疗新靶标，即硫酸软骨素和血红素，以及环子孢子蛋白的使用。许多文章还讨论了伯基特淋巴瘤或发热性中性粒细胞减少症。总体而言，除了Burkitt淋巴瘤外，癌症和疟疾之间的关系还需要进行进一步的广泛研究以明确关联。使用抗疟疾药物的新型抗癌新疗法潜力巨大。使用BioRender创建 以及环子孢子蛋白的用途。许多文章还讨论了伯基特淋巴瘤或发热性中性粒细胞减少症。总体而言，除了Burkitt淋巴瘤外，癌症和疟疾之间的关系还需要进行进一步的广泛研究以明确关联。使用抗疟疾药物的新型抗癌新疗法潜力巨大。使用BioRender创建 以及环子孢子蛋白的用途。许多文章还讨论了伯基特淋巴瘤或发热性中性粒细胞减少症。总体而言，除了Burkitt淋巴瘤外，癌症和疟疾之间的关系还需要进行进一步的广泛研究以明确关联。使用抗疟疾药物的新型抗癌新疗法潜力巨大。使用BioRender创建