Retrotransposons have been known as major sources of genomic instability that trigger and promote cancer development. In a recent study, Gu et al. revealed that MPP8 deficiency impeded tumor development through reactivation long interspersed element-1 (LINE-1 or L1) retrotransposons in acute myeloid leukemia (AML), suggesting a tumor-suppressive role for retrotransposons.

中文翻译：

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逆转录转座子：跳到癌症？

逆转录转座子被认为是引发和促进癌症发展的基因组不稳定性的主要来源。在最近的一项研究中，Gu等人。揭示 MPP8 缺乏通过重新激活急性髓系白血病 (AML) 中长散在的 element-1（LINE-1 或 L1）反转录转座子来阻碍肿瘤发展，表明反转录转座子具有肿瘤抑制作用。