Long-term opioid treatment and endocrine measures in chronic non-cancer pain patients: A systematic review and meta-analysis,European Journal of Pain

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Long-term opioid treatment and endocrine measures in chronic non-cancer pain patients: A systematic review and meta-analysis
European Journal of Pain ( IF 3.5 ) Pub Date : 2021-05-13 , DOI: 10.1002/ejp.1797
Pernille D K Diasso ₁ , Benedikte S Frederiksen ₂ , Susanne D Nielsen ₃ , Katharina M Main ₄ , Per Sjøgren _{1,

5} , Geana P Kurita _{1,

6}

Affiliation

Long-term opioid treatment (L-TOT) of chronic non-cancer pain (CNCP) patients has been suspected to alter the endocrine system. This systematic review and meta-analysis aimed at investigating the published evidence of L-TOT effects on the endocrine system in adult CNCP patients.

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