Today, only few ready-to-use and convenient decision-making tools are available in ecotoxicology concerning accumulation and effects of chemical substances on organisms, accounting for exposure situations that are known to be complex (routes of exposure, metabolism, mixtures, etc.). This paper presents new perspectives on the generic calculation of bioaccumulation metrics via the innovative web tool MOSAIC_bioacc (http://mosaic.univ-lyon1.fr/bioacc). MOSAIC_bioacc provides all kinds of bioaccumulation metrics associated with their uncertainty whatever the species-compound combination. MOSAIC_bioacc expects accumulation-depuration data as inputs, even with complex exposure and clearance patterns, to quickly perform their relevant analysis. MOSAIC_bioacc intends to facilitate the daily work of regulators, or any ecotoxicologist, who will freely benefit from a user-friendly online interface that automatically fits toxicokinetic models without need for users to invest in the technical aspects to get bioaccumulation metrics estimates. MOSAIC_bioacc also provides all results in a fully transparent way to ensure reproducibility. Integr Environ Assess Manag 2022;18:10–18. © 2021 SETAC

中文翻译：

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计算生物体内活性物质的生物累积指标的新观点

今天，在生态毒理学中，关于化学物质对生物体的积累和影响的现成可用和方便的决策工具很少，考虑到已知复杂的暴露情况（暴露途径、代谢、混合物等）。 ）。本文介绍了通过创新的网络工具 MOSAIC _bioacc (http://mosaic.univ-lyon1.fr/bioacc) 对生物累积指标进行通用计算的新观点。MOSAIC _bioacc提供各种与其不确定性相关的生物累积指标，无论物种-化合物组合如何。MOSAIC _bioacc期望积累-净化数据作为输入，即使具有复杂的暴露和清除模式，也能快速执行相关分析。马赛克_bioacc旨在促进监管机构或任何生态毒理学家的日常工作，他们将免费受益于用户友好的在线界面，该界面可自动拟合毒物动力学模型，而无需用户在技术方面进行投资以获得生物蓄积指标估计。MOSAIC _bioacc还以完全透明的方式提供所有结果，以确保可重复性。2022 年整合环境评估管理；18：10–18。© 2021 SETAC