Abstract

1. A common problem in many cancers is the resistance of some patients to common drugs or relapse. Hypoalbuminemia has been reported in some of resistant cancer patients.

2. This article evaluates the usefulness of albumin in the treatment of drug-resistant cancers with hypoalbuminemia based on available evidences.

3. Rapid metabolism and drug excretion from the body is one of the causes of drug resistance. Albumin is the major plasma protein to which almost all drugs are bound. There is some evidence that increasing drug binding to albumin has beneficial effects on drug efficacy in some cancers and cancer cells. On the other hand, some reports have shown that cancer cells can use albumin as the energy and amino acid source.

4. We have hypothesized that in this particular group of cancers, adding albumin to a treatment regimen could have a beneficial effect on drug efficacy and dosage. In fact, excess albumin can prevent rapid metabolism of drug by increasing the fraction of albumin-bound drug, and can increase drug delivery to cancer cells due to the absorption of drug-albumin complex by cancer cells.

摘要

1. 许多癌症的一个常见问题是一些患者对常用药物产生耐药性或复发。一些耐药性癌症患者报告了低白蛋白血症。

2. 本文根据现有证据评估了白蛋白在治疗低白蛋白血症的耐药性癌症中的有效性。

3. 体内快速代谢和药物排泄是产生耐药性的原因之一。白蛋白是主要的血浆蛋白，几乎所有药物都与它结合。有证据表明，增加药物与白蛋白的结合对某些癌症和癌细胞的药效有益。另一方面，一些报道表明癌细胞可以利用白蛋白作为能量和氨基酸来源。

4. 我们假设在这组特定的癌症中，在治疗方案中添加白蛋白可能对药物疗效和剂量产生有益影响。事实上，过量的白蛋白可以通过增加白蛋白结合药物的比例来阻止药物的快速代谢，并且由于癌细胞对药物-白蛋白复合物的吸收，可以增加药物向癌细胞的输送。