Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecule metabolites that like other -omics technologies can provide critical information about the cancer state that are otherwise not apparent. Here, the authors review how cancer and cancer therapies interact with metabolism at the cellular and systemic levels. An overview of metabolomics is provided with a focus on currently available technologies and how they have been applied in the clinical and translational research setting. The authors also discuss how metabolomics could be further leveraged in the future to improve the management of patients with cancer.

中文翻译：

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癌症研究中的代谢组学和临床肿瘤学的新兴应用


癌症对新陈代谢有多种影响，包括细胞内代谢的重新布线，使癌细胞能够不适当地增殖并适应肿瘤微环境，以及正常组织代谢的变化。随着人们认识到氟脱氧葡萄糖-正电子发射断层扫描成像是治疗许多癌症的重要工具，生物样品中的其他代谢物也成为癌症诊断、监测和治疗的焦点。代谢组学是对小分子代谢物的整体分析，与其他组学技术一样，可以提供有关癌症状态的关键信息，而这些信息在其他情况下是不明显的。在这里，作者回顾了癌症和癌症治疗如何在细胞和系统水平上与新陈代谢相互作用。概述了代谢组学，重点关注当前可用的技术以及它们如何应用于临床和转化研究环境。作者还讨论了未来如何进一步利用代谢组学来改善癌症患者的管理。