The Janus kinase (JAK), signal transducer of activation (STAT) pathway, discovered by investigating interferon gene induction, is now recognized as an evolutionary conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. Since its discovery, this pathway has become a paradigm for membrane-to-nucleus signaling and explains how a broad range of soluble factors such as cytokines and hormones, mediate their diverse functions. The understanding of JAK-STAT signaling in the intestine has not only impacted basic science research, particularly in the understanding of intercellular communication and cell-extrinsic control of gene expression, but it has also become a prototype for transition of bench to bedside research, culminating in the clinical implementation of pathway-specific therapeutics.

通过研究干扰素基因诱导发现的 Janus 激酶 (JAK)，即激活信号转导 (STAT) 通路，现在被认为是多种细胞因子、干扰素、生长因子和相关分子采用的进化保守信号通路。自发现以来，该途径已成为膜到细胞核信号传导的范例，并解释了多种可溶性因子（如细胞因子和激素）如何介导它们的不同功能。对肠道中 JAK-STAT 信号传导的理解不仅影响了基础科学研究，特别是对细胞间通讯和细胞外基因表达控制的理解，而且它也成为了从实验室向床边研究过渡的原型，最终达到顶峰。在通路特异性治疗的临床实施中。