Sexual and gender minority (SGM) adolescents assigned male at birth are at increased risk for HIV infection. Pre-exposure prophylaxis (PrEP) is a daily pill taken to prevent HIV, which the United States Food and Drug Administration approved for minors under age 18 years weighing at least 77.5 lb in 2018. A lack of awareness and knowledge of PrEP are barriers to uptake among adults and adolescents, but SGM adolescents’ awareness and knowledge about PrEP remain underexplored and no studies have assessed SGM adolescents’ informational needs. We collected data on 59 SGM adolescents’ (ages 14–18 years) awareness, knowledge, and questions about PrEP in an online survey and six online focus groups. Although a majority of SGM adolescents (83.1%) were aware of PrEP before the study, many wanted more information about side effects and how to navigate potential barriers to PrEP initiation. Findings can inform public health efforts to promote PrEP knowledge and uptake among SGM adolescents.

出生时被分配为男性的性和性别少数 (SGM) 青少年感染 HIV 的风险增加。暴露前预防 (PrEP) 是一种每日服用的预防 HIV 的药丸，美国食品和药物管理局在 2018 年批准用于体重至少 77.5 磅的 18 岁以下未成年人。缺乏对 PrEP 的认识和知识是预防艾滋病毒的障碍。但 SGM 青少年对 PrEP 的认识和知识仍未得到充分探索，也没有研究评估 SGM 青少年的信息需求。我们在一项在线调查和六个在线焦点小组中收集了 59 名 SGM 青少年（14-18 岁）对 PrEP 的认识、知识和问题的数据。尽管大多数 SGM 青少年 (83.1%) 在研究前都知道 PrEP，许多人想要了解更多关于副作用以及如何克服启动 PrEP 的潜在障碍的信息。调查结果可以为公共卫生工作提供信息，以促进 SGM 青少年的 PrEP 知识和吸收。