Sexual and gender minority (SGM) adolescents assigned male at birth are at increased risk for HIV infection. Pre-exposure prophylaxis (PrEP) is a daily pill taken to prevent HIV, which the United States Food and Drug Administration approved for minors under age 18 years weighing at least 77.5 lb in 2018. A lack of awareness and knowledge of PrEP are barriers to uptake among adults and adolescents, but SGM adolescents’ awareness and knowledge about PrEP remain underexplored and no studies have assessed SGM adolescents’ informational needs. We collected data on 59 SGM adolescents’ (ages 14–18 years) awareness, knowledge, and questions about PrEP in an online survey and six online focus groups. Although a majority of SGM adolescents (83.1%) were aware of PrEP before the study, many wanted more information about side effects and how to navigate potential barriers to PrEP initiation. Findings can inform public health efforts to promote PrEP knowledge and uptake among SGM adolescents.

出生时被指定为男性的性少数和性别少数 (SGM) 青少年感染艾滋病毒的风险增加。暴露前预防 (PrEP) 是一种每日服用的药物，用于预防 HIV，美国食品和药物管理局于 2018 年批准用于体重至少 77.5 磅的 18 岁以下未成年人。缺乏对 PrEP 的认识和知识是预防 HIV 的障碍。成人和青少年对 PrEP 的了解程度较高，但 SGM 青少年对 PrEP 的认识和知识仍未得到充分探索，也没有研究评估 SGM 青少年的信息需求。我们通过在线调查和六个在线焦点小组收集了 59 名 SGM 青少年（14-18 岁）对 PrEP 的认知、知识和问题的数据。尽管大多数 SGM 青少年 (83.1%) 在研究前就了解 PrEP，但许多人希望了解更多有关副作用以及如何克服启动 PrEP 的潜在障碍的信息。研究结果可为公共卫生工作提供信息，以促进 SGM 青少年对 PrEP 的了解和采用。