Disseminated candidiasis is a hospital-acquired infection that results in high degree of mortality despite antifungal treatment. Autopsy studies revealed that kidneys are the major target organs in disseminated candidiasis and death due to kidney damage is a frequent outcome in these patients. Thus, the need for effective therapeutic strategies to mitigate kidney damage in disseminated candidiasis is compelling. Recent studies have highlighted the essential contribution of kidney-specific immune response in host defense against systemic infection. Crosstalk between kidney-resident and infiltrating immune cells aid in the clearance of fungi and prevent tissue damage in disseminated candidiasis. In this review, we provide our recent understanding on antifungal immunity in the kidney with an emphasis on IL-17-mediated renal defense in disseminated candidiasis.

播散性念珠菌病是一种医院获得性感染，尽管进行了抗真菌治疗，但仍会导致高死亡率。尸检研究表明，肾脏是播散性念珠菌病的主要靶器官，因肾脏损伤导致的死亡是这些患者的常见结局。因此，需要有效的治疗策略来减轻播散性念珠菌病的肾脏损害。最近的研究强调了肾脏特异性免疫反应在宿主防御全身感染中的重要贡献。肾脏驻留细胞和浸润性免疫细胞之间的串扰有助于清除真菌并防止播散性念珠菌病的组织损伤。在这篇评论中，