Antitubercular lanostane triterpenoids isolated from mycelial cultures of the basidiomycete Ganoderma australe were structurally modified by semisynthesis. One of the synthetic compounds, named GA003 (9), showed more potent activity against Mycobacterium tuberculosis H37Ra than the lead natural lanostane (1). GA003 was also significantly active against the virulent strain (H37Rv) as well as extensively drug-resistant tuberculosis strains.

中文翻译：

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灵芝抗结核羊毛甾烷三萜类化合物的半合成修饰

从担子菌Ganoderma australe的菌丝体培养物中分离出的抗结核羊毛甾烷三萜类化合物通过半合成进行了结构修饰。其中一种名为 GA003 ( 9 ) 的合成化合物比主要的天然羊毛甾烷 ( 1 ) 显示出更有效的抗结核分枝杆菌H37Ra 活性。 GA003 对强毒株 (H37Rv) 以及广泛耐药结核株也具有显着活性。