There are several examples in the nature wherein the mechanism of longevity control of unicellular organisms is evolutionarily conserved with that of higher multicellular organisms. The present microreview focuses on aging and longevity studies, particularly on chronological lifespan (CLS) concerning the unicellular eukaryotic fission yeast Schizosaccharomyces pombe. In S. pombe, >30 compounds, 8 types of nutrient restriction, and >80 genes that extend CLS have been reported. Several CLS control mechanisms are known to be involved in nutritional response, energy utilization, stress responses, translation, autophagy, and sexual differentiation. In unicellular organisms, the control of CLS is directly linked to the mechanism by which cells are maintained in limited-resource environments, and their genetic information is left to posterity. We believe that this important mechanism may have been preserved as a lifespan control mechanism for higher organisms.

中文翻译：

---

粟酒裂殖酵母按时间顺序寿命的延长

自然界中有几个例子，其中单细胞生物的寿命控制机制在进化上与高等多细胞生物的机制一样。目前的微观评论侧重于衰老和长寿研究，特别是关于单细胞真核分裂酵母粟酒裂殖酵母的时间寿命 (CLS) 。在庞贝，>30 种化合物，8 种营养限制类型，以及 >80 种扩展 CLS 的基因已被报道。已知几种 CLS 控制机制涉及营养反应、能量利用、应激反应、翻译、自噬和性分化。在单细胞生物中，CLS 的控制与细胞在资源有限的环境中维持的机制直接相关，它们的遗传信息留给后代。我们认为，这一重要机制可能已被保存为高等生物的寿命控制机制。