Aim

This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes.

Methods

For 118 diabetic patients, laboratory measurements and clinical outcomes were compared between males and females. This study also compared inflammatory ratios obtained from combinations of six inflammatory markers between the two groups. The risk factors for mortality were identified through logistic regression.

Results

Males were 54 (45.8%) and females were 64 (54.2%). Males showed a significant increase in ALT (P = 0.003), CRP (P = 0.03), mean platelet volume (MPV)-to-lymphocyte ratio (P = 0.001), and C-reactive protein-to-albumin ratio (P = 0.044), whereas females had a significant increase in lymphocytes (P < 0.005) and MPV (P = 0.01). In all participants, multivariate analysis illustrated that older age, male sex, increased serum total bilirubin, and decreased PO₂ were significant independent predictors of mortality (P < 0.05).

Conclusion

In severe COVID-19 patients with diabetes, there were significant sex differences in many laboratory characteristics with a higher risk of mortality among males.

中文翻译：

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重症 COVID-19 糖尿病患者实验室参数的性别相关差异：一项回顾性队列研究

目的

本研究旨在提供证据，以考虑在解读重症 COVID-19 糖尿病患者实验室参数时的性别差异。

方法

对 118 名糖尿病患者的男性和女性实验室测量结果和临床结果进行了比较。这项研究还比较了两组之间六种炎症标志物组合获得的炎症比率。通过逻辑回归确定死亡的危险因素。

结果

男性 54 人（45.8%），女性 64 人（54.2%）。男性的 ALT (P = 0.003)、CRP (P = 0.03)、平均血小板体积 (MPV) 与淋巴细胞比率 (P = 0.001) 和 C 反应蛋白与白蛋白比率 (P = 0.044），而女性淋巴细胞（P < 0.005）和 MPV（P = 0.01）显着增加。在所有参与者中，多变量分析表明，年龄较大、男性、血清总胆红素升高和 PO ₂降低是死亡率的显着独立预测因素（P < 0.05）。

结论

在患有糖尿病的重症 COVID-19 患者中，许多实验室特征存在显着的性别差异，其中男性死亡风险较高。