The Borrelia spp. are tick-borne pathogenic spirochetes that include the agents of Lyme disease and relapsing fever. As part of their life cycle, the spirochetes traffic between the tick vector and the vertebrate host, which requires significant physiological changes and remodeling of their outer membranes and proteome. This crucial proteome resculpting is carried out by a diverse set of proteases, adaptor proteins, and related chaperones. Despite its small genome, Borrelia burgdorferi has dedicated a large percentage of its genome to proteolysis, including a full complement of ATP-dependent proteases. Energy-driven proteolysis appears to be an important physiological feature of this dual-life-cycle bacterium. The proteolytic arsenal of Borrelia is strategically deployed for disposal of proteins no longer required as they move from one stage to another or are transferred from one host to another. Likewise, the Borrelia spp. are systemic organisms that need to break down and move through host tissues and barriers, and so their unique proteolytic resources, both endogenous and borrowed, make movement more feasible. Both the Lyme disease and relapsing fever Borrelia spp. bind plasminogen as well as numerous components of the mammalian plasminogen-activating system. This recruitment capacity endows the spirochetes with a borrowed proteolytic competency that can lead to increased invasiveness.

中文翻译：

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疏螺旋体的内源性和借用蛋白水解活性

疏螺旋体属。是蜱传播的致病性螺旋体，包括莱姆病和回归热的病原体。作为其生命周期的一部分，蜱虫载体和脊椎动物宿主之间的螺旋体交通，这需要显着的生理变化和重塑其外膜和蛋白质组。这种关键的蛋白质组重塑是由一组不同的蛋白酶、衔接蛋白和相关伴侣进行的。尽管其基因组很小，伯氏疏螺旋体已将其大部分基因组用于蛋白水解，包括完整的 ATP 依赖性蛋白酶。能量驱动的蛋白水解似乎是这种双生命周期细菌的重要生理特征。疏螺旋体的蛋白水解武器库战略性地部署用于处理不再需要的蛋白质，因为它们从一个阶段移动到另一个阶段或从一个宿主转移到另一个宿主。同样，疏螺旋体属。是系统性有机体，需要分解并穿过宿主组织和屏障，因此它们独特的内源性和借用蛋白水解资源使运动更加可行。莱姆病和回归热Borrelia spp。结合纤溶酶原以及哺乳动物纤溶酶原激活系统的许多成分。这种招募能力赋予螺旋体一种借来的蛋白水解能力，从而增加侵袭性。