Lead (Pb) poses a potential environmental risk factor for cognitive dysfunction during early life and childhood. Resveratrol is considered a promising antioxidant with respect to the prevention of cognitive deficits and act as a potent SIRT1 agonist. Herein, this study aims to investigate the profile of neurogenesis markers following Pb exposure and to determine the regulatory role of resveratrol in this process. We confirmed firstly the protective effects of resveratrol against Pb-induced impairments of hippocampal neurogenesis in Male SD rats. Pb exposure early in life caused the altered expression of Ki-67, NeuN, caspase-3 and SIRT1 signaling, thereby resulting in spatial cognitive impairment of adolescent rats. As expected, resveratrol reduced cognitive damage and promoted neurogenesis in Pb-induced injury by regulation of SIRT1 pathway. Collectively, our study establishes the efficacy of resveratrol as a neuroprotective agent and provides a strong rationale for further studies on SIRT1-mediated mechanisms of neuroprotective functions.

中文翻译：

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白藜芦醇通过激活 SIRT1 信号传导改善大鼠铅暴露后的海马神经发生

铅 (Pb) 是生命早期和儿童时期认知功能障碍的潜在环境风险因素。白藜芦醇被认为是一种有前途的抗氧化剂，可预防认知缺陷，并作为有效的 SIRT1 激动剂。在此，本研究旨在调查铅暴露后神经发生标志物的分布，并确定白藜芦醇在此过程中的调节作用。我们首先证实了白藜芦醇对铅诱导的雄性 SD 大鼠海马神经发生损伤的保护作用。生命早期铅暴露导致 Ki-67、NeuN、caspase-3 和 SIRT1 信号的表达改变，从而导致青春期大鼠的空间认知障碍。正如预期的那样，白藜芦醇通过调节 SIRT1 通路减少了 Pb 诱导的损伤中的认知损伤并促进了神经发生。