Hexavalent chromium (Cr (VI)), which is a recognized human carcinogen, is widely used in industrial production of raw materials. Evidence verifies that environmental contaminants in the urine can induce malignant transformation in the urinary bladder tract, and our data indicate that Cr (VI) could promote the proliferation and migration and inhibit the apoptosis of bladder cancer (BLCA) cells. However, the molecular mechanism remains ambiguous. We find that Filamin A (FLNA) is overexpressed in BLCA, and Cr (VI) promotes epithelial-to-mesenchymal transition by regulating FLNA in BLCA. Thus, inhibiting the expression of FLNA may be a prospective method for limiting the BLCA progression caused by Cr (VI) exposure.

中文翻译：

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铬 (VI) 通过调节 BLCA 中的 FLNA 促进 EMT

六价铬(Cr(VI))是公认的人类致癌物，广泛用于工业生产原料。有证据证实尿液中的环境污染物可诱导膀胱道恶性转化，我们的数据表明Cr（VI）可以促进膀胱癌（BLCA）细胞的增殖和迁移，抑制细胞凋亡。然而，分子机制仍然模棱两可。我们发现细丝蛋白 A (FLNA) 在 BLCA 中过表达，而 Cr (VI) 通过调节 BLCA 中的 FLNA 促进上皮间质转化。因此，抑制 FLNA 的表达可能是限制 Cr (VI) 暴露引起的 BLCA 进展的一种前瞻性方法。