Antiviral and Anti-Inflammatory Treatment with Multifunctional Alveolar Macrophage-Like Nanoparticles in a Surrogate Mouse Model of COVID-19,Advanced Science

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Antiviral and Anti-Inflammatory Treatment with Multifunctional Alveolar Macrophage-Like Nanoparticles in a Surrogate Mouse Model of COVID-19
Advanced Science ( IF 14.3 ) Pub Date : 2021-05-12 , DOI: 10.1002/advs.202003556
Bin Li _{1,

2} , Wei Wang _{1,

3} , Weifeng Song ₁ , Zheng Zhao ₄ , Qingqin Tan _{1,

2} , Zhaoyan Zhao _{1,

2} , Lantian Tang _{1,

2} , Tianchuan Zhu _{1,

2} , Jialing Yin _{1,

2} , Jun Bai _{1,

2} , Xin Dong _{1,

2} , Siyi Tan _{1,

2} , Qunying Hu ₃ , Ben Zhong Tang ₄ , Xi Huang _{1,

2}

Affiliation

The pandemic of coronavirus disease 2019 (COVID-19) is continually worsening. Clinical treatment for COVID-19 remains primarily supportive with no specific medicines or regimens. Here, the development of multifunctional alveolar macrophage (AM)-like nanoparticles (NPs) with photothermal inactivation capability for COVID-19 treatment is reported. The NPs, made by wrapping polymeric cores with AM membranes, display the same surface receptors as AMs, including the coronavirus receptor and multiple cytokine receptors. By acting as AM decoys, the NPs block coronavirus from host cell entry and absorb various proinflammatory cytokines, thus achieving combined antiviral and anti-inflammatory treatment. To enhance the antiviral efficiency, an efficient photothermal material based on aggregation-induced emission luminogens is doped into the NPs for virus photothermal disruption under near-infrared (NIR) irradiation. In a surrogate mouse model of COVID-19 caused by murine coronavirus, treatment with multifunctional AM-like NPs with NIR irradiation decreases virus burden and cytokine levels, reduces lung damage and inflammation, and confers a significant survival advantage to the infected mice. Crucially, this therapeutic strategy may be clinically applied for the treatment of COVID-19 at early stage through atomization inhalation of the NPs followed by NIR irradiation of the respiratory tract, thus alleviating infection progression and reducing transmission risk.

中文翻译：

在 COVID-19 的替代小鼠模型中使用多功能肺泡巨噬细胞样纳米颗粒进行抗病毒和抗炎治疗

2019 年冠状病毒病 (COVID-19) 的大流行正在不断恶化。COVID-19 的临床治疗仍然主要是支持性的，没有特定的药物或方案。在这里，报道了具有光热灭活能力的多功能肺泡巨噬细胞 (AM) 样纳米粒子 (NPs) 用于 COVID-19 治疗的开发。通过用 AM 膜包裹聚合物核心制成的 NP，显示出与 AM 相同的表面受体，包括冠状病毒受体和多种细胞因子受体。通过充当AM诱饵，NPs阻止冠状病毒进入宿主细胞并吸收各种促炎细胞因子，从而实现抗病毒和抗炎的联合治疗。为了提高抗病毒效率，一种基于聚集诱导发光的高效光热材料被掺杂到纳米颗粒中，用于在近红外 (NIR) 照射下进行病毒光热破坏。在由鼠冠状病毒引起的 COVID-19 替代小鼠模型中，用 NIR 照射的多功能 AM 样 NPs 治疗可降低病毒负荷和细胞因子水平，减少肺损伤和炎症，并为受感染的小鼠带来显着的生存优势。至关重要的是，这种治疗策略可以通过雾化吸入纳米颗粒，然后对呼吸道进行 NIR 照射，在早期临床上应用于 COVID-19 的治疗，从而缓解感染进展并降低传播风险。在由鼠冠状病毒引起的 COVID-19 替代小鼠模型中，用 NIR 照射的多功能 AM 样 NPs 治疗可降低病毒负荷和细胞因子水平，减少肺损伤和炎症，并为受感染的小鼠带来显着的生存优势。至关重要的是，这种治疗策略可以通过雾化吸入纳米颗粒，然后对呼吸道进行 NIR 照射，在早期临床上应用于 COVID-19 的治疗，从而缓解感染进展并降低传播风险。在由鼠冠状病毒引起的 COVID-19 替代小鼠模型中，用 NIR 照射的多功能 AM 样 NPs 治疗可降低病毒负荷和细胞因子水平，减少肺损伤和炎症，并为受感染的小鼠带来显着的生存优势。至关重要的是，这种治疗策略可以通过雾化吸入纳米颗粒，然后对呼吸道进行 NIR 照射，在早期应用于 COVID-19 的临床治疗，从而减轻感染进展并降低传播风险。

更新日期：2021-07-07

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