Objective:

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that is associated with cognitive disabilities, including attention and motor learning problems. These disabilities have been extensively studied in children with NF1 but limited studies have been performed in adults.

Method:

Attention, motor learning and intellectual performance were studied with neuropsychological tasks in 32 adults with NF1 and 32 controls.

Results:

The NF1 and control group performed similarly on attention and motor learning tasks, although controls had shorter reaction times than adults with NF1 during the motor learning task (t[60] = −2.20, p = .03). Measures of attention or motor learning were not significantly associated with reduced intellectual performance in NF1.

Conclusion:

In contrast to many studies in children with NF1, our findings did not provide evidence for presence of attention or motor learning problems in adults with NF1 in neuropsychological tasks. Our observations may be of clinical importance to determine treatment focus in adults with NF1.

中文翻译：

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1型神经纤维瘤病成人患者的注意力和运动学习

客观的：

1 型神经纤维瘤病 (NF1) 是一种常染色体显性遗传疾病，与认知障碍有关，包括注意力和运动学习问题。这些残疾已在患有 NF1 的儿童中进行了广泛的研究，但在成人中进行的研究有限。

方法：

对 32 名患有 NF1 的成年人和 32 名对照者的神经心理学任务研究了注意力、运动学习和智力表现。

结果：

NF1 组和对照组在注意力和运动学习任务上的表现相似，尽管对照组在运动学习任务中的反应时间比 NF1 成人短 ( t [60] = -2.20, p  = .03)。注意力或运动学习的测量与 NF1 中智力表现的下降没有显着相关性。

结论：

与许多针对 NF1 儿童的研究相比，我们的研究结果并未提供证据证明 NF1 成人在神经心理学任务中存在注意力或运动学习问题。我们的观察结果可能对确定 NF1 成人的治疗重点具有重要的临床意义。