Pancreatic cancer is a common malignant tumor worldwide. Extensive studies have been conducted on the functional role of long noncoding RNAs in pancreatic cancer. In this study, long intergenic nonprotein coding RNA 173 (LINC00173) was highly expressed in pancreatic cancer tissues. In vitro functional experiments showed that LINC00173 overexpression inhibited the proliferation and invasion of pancreatic cancer cells and promoted cell apoptosis in MIA PaCa-2 and PANC-1 cells.

中文翻译：

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长基因间非蛋白编码 RNA 173 通过抑制胰腺癌中鞘氨醇激酶 1 蛋白的表达来抑制肿瘤生长并促进细胞凋亡

胰腺癌是世界范围内常见的恶性肿瘤。已经对长链非编码 RNA 在胰腺癌中的功能作用进行了广泛的研究。在这项研究中，长基因间非蛋白编码 RNA 173 (LINC00173) 在胰腺癌组织中高表达。体外功能实验表明，LINC00173过表达抑制了胰腺癌细胞的增殖和侵袭，促进了MIA PaCa-2和PANC-1细胞的细胞凋亡。