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Investigations of gold nanoparticles-mediated carbon nanotube reinforced hydroxyapatite composite for bone regenerations
Journal of Saudi Chemical Society ( IF 5.8 ) Pub Date : 2021-05-12 , DOI: 10.1016/j.jscs.2021.101261
Songchuan Zhao , Wei Cui , Naresh Kumar Rajendran , Fei Su , Mariappan Rajan

An excellent combination of biomaterials permits prompt features and high-throughput investigations in various fields, particularly in the biomedical applications. This article investigates the bone regeneration ability and compatibility of the Gold (Au) Nanoparticles (NPs) medicated carbon nanotube reinforced hydroxyapatite (HAP) composite. The morphologies of the synthesized Au NPs, HAP and HAP/CNT, and HAP/CNT-Au composites vary suggestively with modifying the components and the final composite showing as bone mimic extracellular matrix morphology. The structure, phase, and composition of the as-synthesized HAP were studied by FTIR, XRD, EDAX, and TEM techniques. The materials' biocompatibility was investigated in the Stimulated Body Fluid (SBF) solution, which resulted in the composite having good biocompatibility, bioactivity nature and hydroxyapatite layer formed on the composite surface. The composite shows good viability with Adipose Tissue-derived Stem Cells (ADSC) to cell growth and cell proliferation in the biological evaluation. It represented the composites having a good ability for cell formation development. Since the HAP/CNT-Au composite are useful in medicinal applications such as orthopedic and orthodontic repair/regenerations after the evaluations of animal and clinical investigations.



中文翻译:

金纳米粒子介导的碳纳米管增强羟基磷灰石复合材料促进骨再生的研究

生物材料的完美结合可在各个领域,特别是在生物医学应用中提供快速的功能和高通量的研究。本文研究了金(Au)纳米颗粒(NPs)含药的碳纳米管增强羟基磷灰石(HAP)复合材料的骨再生能力和相容性。合成的金纳米颗粒,HAP和HAP / CNT以及HAP / CNT-Au复合材料的形态随着修饰成分的变化而变化,最终的复合材料表现为骨模拟的细胞外基质形态。通过FTIR,XRD,EDAX和TEM技术研究了合成后的HAP的结构,相和组成。在受激体液(SBF)溶液中研究了材料的生物相容性,从而使复合材料具有良好的生物相容性,具有生物活性的性质和在复合材料表面形成的羟基磷灰石层。在生物学评估中,该复合材料与脂肪组织衍生的干细胞(ADSC)在细胞生长和细胞增殖方面显示出良好的生存能力。它代表了具有良好细胞形成能力的复合材料。由于HAP / CNT-Au复合材料在评估动物和临床研究后可用于医学应用,例如整形外科和正畸修复/再生。

更新日期:2021-05-25
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