Amomum villosum Lour. is commonly used in Asian countries as an herbal remedy to medicate several diseases including type 2 diabetes. In this animal experiment, we examined the influence of Amomum villosum water extract (AVE) against metabolic variations in high-fat diet (HFD)-induced obesity in C57BL/6 mice. Mice were nourishing with a normal diet (control), high-fat diet (HFD), HFD + AVE 100 mg/kg body weight (b.wt.)/day, HFD + AVE 200 mg/kg b.wt./day, and HFD + AVE 500 mg/kg b.wt./day for 7 weeks. The AVE (100, 200, and 500 mg/kg)-treated animals exhibited substantial decreases in body mass, fat mass, adipocyte hypertrophy, and epididymal white adipose tissue (eWAT) collate to the HFD-fed group. AVE treatment also reduced hepatic triglyceride level and significantly increased the adiponectin expression in adipocytes. Furthermore, AVE treatment significantly inhibited adipogenesis in the AVE group by reducing the mRNA expression of sterol regulatory element-binding protein1 (SREBP1), fatty acid synthase (FAS), CCAAT/enhancer binding protein (C/EBP)-α, peroxisome proliferator-activated receptor (PPAR)-γ, and tumor necrosis factor (TNF)-α agreeing to the HFD-fed animals. These research outcomes recommend that AVE is possibly valuable for the prevention of HFD-induced obesity via modification of various pathways related with adipogenesis and food consumption.

砂仁砂仁。在亚洲国家通常用作草药治疗多种疾病，包括 2 型糖尿病。在这个动物实验中，我们研究了砂仁的影响水提取物 (AVE) 对抗高脂肪饮食 (HFD) 诱导的 C57BL/6 小鼠肥胖的代谢变化。小鼠用正常饮食（对照）、高脂肪饮食（HFD）、HFD + AVE 100 mg/kg 体重（b.wt.）/天、HFD + AVE 200 mg/kg b.wt./天进行营养和 HFD + AVE 500 毫克/公斤体重/天，持续 7 周。AVE（100、200 和 500 毫克/千克）处理的动物表现出体重、脂肪量、脂肪细胞肥大和附睾白色脂肪组织 (eWAT) 与HFD 喂养组的显着减少。AVE 治疗还降低了肝脏甘油三酯水平并显着增加了脂肪细胞中脂联素的表达。此外，AVE 治疗通过降低甾醇调节元件结合蛋白 1 (SREBP1)、脂肪酸合酶 (FAS)、 (PPAR)-γ 和肿瘤坏死因子 (TNF)-α 与 HFD 喂养的动物一致。这些研究结果表明，AVE 可能通过改变与脂肪生成和食物消耗相关的各种途径来预防 HFD 诱导的肥胖。