Abstract

Aim

The aim of this study was to determine the change in facial skin sebum, hydration and elasticity of acne vulgaris patients after being treated with systemic isotretinoin.

Method

Patients who were diagnosed with acne vulgaris and who received systemic isotretinoin treatment for 6 months in Cerrahpaşa Medical Faculty Department of Dermatology between June 2012 and May 2017 were included in this study. The sebum, hydration and elasticity of the skin were measured non-invasively with a device called “Soft Plus Skin Analyses System” before treatment and 6 months after treatment. The relationship between the pre-treatment and post-treatment values were evaluated statistically. 35 adult patients (20 female, 15 male) who were diagnosed with acne vulgaris and who received systemic isotretinoin treatment for 6 months.

Results

The pre-treatment sebum value for both sexes ranged between 5 and 100 and the mean value was calculated as 75.8 $\pm$ 28.0. The post-treatment sebum values ranged between 1 and 98 and the mean value was calculated as 48.4 $\pm$ 31.8. The difference between the pre-treatment and post-treatment values was statistically significant, p < 0.001. The decline in sebum value after treatment was 36%. The pre-treatment hydration values ranged between 9 and 77.5 and the mean was 34.6 $\pm$ 14.6. The post treatment hydration values ranged between 4.8 and 100 and the mean was calculated as 62.4 $\pm$ 28.6. The difference between the pre-treatment and post-treatment hydration values were statistically significant, p < 0.001. The post-treatment increase in hydration was 79%. The pre-treatment skin elasticity ranged between 28 and 50; the mean was 40.4 $\pm$ 5.5. The post-treatment elasticity values ranged between 20 and 50; and the mean was 37.5 $\pm$ 8.2. However, the difference was not statistically significant (p = 0.1).

Conclusion

With this study, it was concluded that, systemic isotretion leads to a 36% decline in skin sebum values and a 79% increase in the skin hydration. However, the change in skin elasticity was not statistically significant. Furthermore, the changes in sebum and skin hydration did not lead to a change in skin elasticity.

中文翻译：

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接受全身异维A酸治疗的寻常痤疮患者皮脂、保湿和弹性变化的评价

摘要

目标

本研究的目的是确定全身性异维A酸治疗后寻常痤疮患者面部皮肤皮脂、水分和弹性的变化。

方法

本研究纳入了 2012 年 6 月至 2017 年 5 月在 Cerrahpaşa 医学院皮肤科诊断为寻常痤疮并接受了 6 个月全身异维A酸治疗的患者。在治疗前和治疗后 6 个月，使用名为“Soft Plus 皮肤分析系统”的设备以非侵入性方式测量皮肤的皮脂、水分和弹性。统计评估治疗前和治疗后值之间的关系。35 名成年患者（20 名女性，15 名男性）被诊断出患有寻常痤疮并接受了 6 个月的全身异维A酸治疗。

结果

两性的治疗前皮脂值介于 5 和 100 之间，平均值计算为 75.8 $\pm$ 28.0. 治疗后的皮脂值介于 1 和 98 之间，平均值计算为 48.4 $\pm$ 31.8. 治疗前和治疗后值之间的差异具有统计学意义，p  < 0.001。治疗后皮脂值下降36%。预处理水化值介于 9 和 77.5 之间，平均值为 34.6 $\pm$ 14.6. 处理后的水合值介于 4.8 和 100 之间，平均值计算为 62.4 $\pm$ 28.6. 治疗前和治疗后水合值之间的差异具有统计学意义，p  < 0.001。处理后的水合作用增加了 79%。治疗前皮肤弹性介于28和50之间；平均值为 40.4 $\pm$ 5.5. 处理后的弹性值介于 20 和 50 之间；平均值为 37.5 $\pm$ 8.2. 然而，差异无统计学意义（p  = 0.1）。

结论

通过这项研究，得出的结论是，全身等渗导致皮肤皮脂值下降 36%，皮肤水合作用增加 79%。然而，皮肤弹性的变化没有统计学意义。此外，皮脂和皮肤水分的变化不会导致皮肤弹性的变化。