Hypercholesterolemia is one of the leading causes of cardiovascular disease. Probiotics can help to improve high blood lipid levels in hypercholesterolemia patients. Lactobacillus paracasei has been reported to have beneficial effects in several subjects; however, there is a lack of studies on Thai hypercholesterolemic subjects. Thus, this study was conducted in order to investigate the effect of L. paracasei HII01 on cholesterol, oxidative stress, and other biomarkers. Fifty-two subjects were randomized into two groups: the L. paracasei treatment group and the placebo group. The study was conducted over an intervention period of 12 weeks of supplementation. The results show that L. paracasei HII01 significantly reduced the total cholesterol (TCH), triglycerides (TGs), tumor necrosis factor (TNF)-α and lipopolysaccharide (LPS) of the patients, and increased their HDL, total antioxidant capacity (TAC) and propionic acid compared to the placebo group. Moreover, the supplementation of L. paracasei HII01 significantly increased lactic acid, IL-10 and IFN-γ, and substantially decreased malondialdehyde (MDA) at the end of the treatment. The results suggest that L. paracasei HII01 improves the blood lipid profile, reduces oxidative stress, and is beneficial for health among Thai hypercholesterolemic subjects.

中文翻译：

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副干酪乳杆菌HII01的添加对泰国高胆固醇血症受试者总胆固醇以及脂质和碳水化合物代谢，氧化应激，炎症和消化参数的影响

高胆固醇血症是心血管疾病的主要原因之一。益生菌可以帮助改善高​​胆固醇血症患者的高血脂水平。据报道，副干酪乳杆菌在一些受试者中具有有益作用。然而，关于泰国高胆固醇血症的研究缺乏研究。因此，进行这项研究是为了研究副干酪乳杆菌HII01对胆固醇，氧化应激和其他生物标志物的影响。52名受试者被随机分为两组：副干酪乳杆菌治疗组和安慰剂组。该研究是在补充12周的干预期内进行的。结果表明副干酪乳杆菌与安慰剂相比，HII01显着降低了患者的总胆固醇（TCH），甘油三酸酯（TGs），肿瘤坏死因子（TNF）-α和脂多糖（LPS），并增加了其HDL，总抗氧化能力（TAC）和丙酸团体。此外，在治疗结束时，副干酪乳杆菌HII01的添加显着增加了乳酸，IL-10和IFN-γ，并显着降低了丙二醛（MDA）。结果表明副干酪乳杆菌HII01改善了血脂状况，降低了氧化应激，并且对泰国高胆固醇血症受试者的健康有益。