Prodromal sensory neuropathy in Pink1−/−SNCAA53T double mutant Parkinson mice,Neuropathology and Applied Neurobiology

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Prodromal sensory neuropathy in Pink1−/−SNCAA53T double mutant Parkinson mice
Neuropathology and Applied Neurobiology ( IF 5 ) Pub Date : 2021-05-11 , DOI: 10.1111/nan.12734
Lucie Valek ₁ , Bao Tran ₁ , Annett Wilken-Schmitz ₁ , Sandra Trautmann ₁ , Juliana Heidler ₂ , Tobias Schmid ₃ , Bernhard Brüne _{3,

4} , Dominique Thomas ₁ , Thomas Deller ₅ , Gerd Geisslinger _{1,

4,

6} , Georg Auburger ₇ , Irmgard Tegeder ₁

Affiliation

Parkinson's disease (PD) is frequently associated with a prodromal sensory neuropathy manifesting with sensory loss and chronic pain. We have recently shown that PD-associated sensory neuropathy in patients is associated with high levels of glucosylceramides. Here, we assessed the underlying pathology and mechanisms in Pink1^−/−SNCA^A53T double mutant mice.

中文翻译：

Pink1-/-SNCAA53T 双突变帕金森小鼠的前驱感觉神经病

帕金森病 (PD) 经常与表现为感觉丧失和慢性疼痛的前驱性感觉神经病变有关。我们最近表明，患者的 PD 相关感觉神经病变与高水平的葡萄糖神经酰胺有关。在这里，我们评估了Pink1 ^-/-SNCA ^A53T双突变小鼠的潜在病理学和机制。

更新日期：2021-05-11

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