当前位置: X-MOL 学术Neuropathol. Appl. Neurobiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Inflammation, fibrosis and skeletal muscle regeneration in LGMDR9 are orchestrated by macrophages
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2021-05-10 , DOI: 10.1111/nan.12730
Heike Kölbel 1 , Corinna Preuße 2, 3 , Lukas Brand 1 , Arpad von Moers 4 , Adela Della Marina 1 , Markus Schuelke 5 , Andreas Roos 1 , Hans-Hilmar Goebel 2, 6 , Ulrike Schara-Schmidt 1 , Werner Stenzel 2
Affiliation  

Variable degrees of inflammation, necrosis, regeneration and fibrofatty replacement are part of the pathological spectrum of the dystrophic process in alpha dystroglycanopathy LGMDR9 (FKRP-related, OMIM #607155), one of the most prevailing types of LGMDs worldwide. Inflammatory processes and their complex interplay with vascular, myogenic and mesenchymal cells may have a major impact on disease development. The purpose of our study is to describe the specific immune morphological features in muscle tissue of patients with LGMDR9 to enable a better understanding of the phenotype of muscle damage leading to disease progression.

中文翻译:

LGMDR9 中的炎症、纤维化和骨骼肌再生由巨噬细胞协调

不同程度的炎症、坏死、再生和纤维脂肪替代是 α 肌营养不良症 LGMDR9(FKRP 相关,OMIM #607155)中营养不良过程的病理谱的一部分,这是全球最流行的 LGMD 类型之一。炎症过程及其与血管、肌​​源性和间充质细胞的复杂相互作用可能对疾病发展产生重大影响。我们研究的目的是描述 LGMDR9 患者肌肉组织中特定的免疫形态学特征,以便更好地了解导致疾病进展的肌肉损伤表型。
更新日期:2021-05-10
down
wechat
bug