Lipid peroxidation (LPO) is the molecular mechanism involved in oxidative damage of cellular membranes and the hallmark of a nonapoptotic form of cell death, known as ferroptosis. This iron-dependent cell death is an emerging strategy in cancer treatment and one of the central cell death mechanisms accounting for early cell loss and organ dysfunction in both neurodegenerative disease and ischemia-reperfusion injury. Although the biological roles of LPO products have attracted considerable attention, not only for their pathological mechanisms but also for their potential clinical application as biomarkers, the existence of a common lethal lipid death signal generated during ferroptosis remains poorly explored. A better understanding of the LPO process, however, may unleash unprecedented opportunities for therapeutic intervention of as-yet incurable diseases.

脂质过氧化 (LPO) 是参与细胞膜氧化损伤的分子机制，也是细胞死亡的非凋亡形式（称为铁死亡）的标志。这种铁依赖性细胞死亡是癌症治疗中的一种新兴策略，也是导致神经退行性疾病和缺血再灌注损伤中早期细胞丢失和器官功能障碍的主要细胞死亡机制之一。尽管 LPO 产品的生物学作用引起了相当大的关注，不仅因为它们的病理机制，而且因为它们作为生物标志物的潜在临床应用，但在铁死亡过程中产生的常见致死脂质死亡信号的存在仍然很少被探索。然而，更好地理解 LPO 流程，