Over the last four decades, birth cohort studies have materially improved our understanding of the early origins of respiratory disease. In this issue, Belinelo et al present evidence from the bern infant lung development (BILD) and breathing for life trial (BLT) cohorts demonstrating that maternal asthma is associated with altered tidal breathing patterns in male infants.1 The BILD cohort recruited healthy neonates from 1999 to 2010 to further understand the complex interactions of environment and genetics on lung development and respiratory disease. In contrast, the BLT was a clinical trial to investigate the utility of the fractional concentration of exhaled nitric oxide in guiding medical management of asthma in pregnant women which included prospective infant follow-up. This analysis uses a combined data set of the two cohorts to look at the link between maternal asthma and tidal breathing parameters in young infants.1 The authors found that male infants born to mothers with asthma had a lower ratio of the time to peak tidal expiratory flow to total expiratory time (tPTEF/tE%).1 This breathing pattern is compatible with a longer respiratory system time constant and has been shown to be associated with later wheezing in early life2 and asthma up to age 36.3 Low lung function in infancy not only precedes and predicts later respiratory problems it also seems to partly determine …

中文翻译：

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性别在肺发育中很重要的进一步证据：母亲哮喘和婴儿肺功能

在过去的四年里，出生队列研究极大地提高了我们对呼吸系统疾病早期起源的理解。在本期中，Belinelo 等人提供了来自伯尔尼婴儿肺发育 (BILD) 和终生呼吸试验 (BLT) 队列的证据，证明母亲哮喘与男性婴儿潮汐呼吸模式的改变有关。 1 BILD 队列从来自1999 年至 2010 年，以进一步了解环境和遗传学对肺发育和呼吸系统疾病的复杂相互作用。相比之下，BLT 是一项临床试验，旨在研究呼出的一氧化氮浓度分数在指导孕妇哮喘医疗管理中的作用，包括对婴儿进行前瞻性随访。