Our study was aimed to analyze the osteoinductive effect of powdered and block type autogenous bone graft along with bone morphogenetic protein (BMP-2) as compared to synthetic bone graft. Three circular bicortical defects were made in the calvaria of each rabbit and randomly divided into three groups as follows: powdered tooth biomaterial+BMP-2, block tooth biomaterial+BMP-2, and control group: synthetic bone+BMP-2. The samples taken from these defects after 4 and 8 weeks were analyzed histologically along with micro CT analysis. In our study, both powered and block type tooth autogenous bone graft successfully stimulated mesenchymal cells leading to endochondral ossification and bone regeneration. We observed that the powered bone graft material which is acid insoluble especially is preferable as a carrier for BMP-2.

中文翻译：

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使用带有 BMP-2 的牙齿生物材料对兔颅骨缺损进行骨再生的微计算机断层扫描和组织学研究


我们的研究旨在分析粉末状和块状自体骨移植物以及骨形态发生蛋白（BMP-2）与合成骨移植物相比的骨诱导效果。在每只兔子的颅骨上制作三个圆形双皮质缺损，随机分为三组：粉状牙生物材料+BMP-2，块状牙生物材料+BMP-2，对照组：合成骨+BMP-2。 4 周和 8 周后从这些缺陷中采集的样本进行组织学分析以及显微 CT 分析。在我们的研究中，动力型和块状牙齿自体骨移植都成功地刺激了间充质细胞，导致软骨内骨化和骨再生。我们观察到酸不溶性粉末骨移植材料特别优选作为BMP-2的载体。