Our study was aimed to analyze the osteoinductive effect of powdered and block type autogenous bone graft along with bone morphogenetic protein (BMP-2) as compared to synthetic bone graft. Three circular bicortical defects were made in the calvaria of each rabbit and randomly divided into three groups as follows: powdered tooth biomaterial+BMP-2, block tooth biomaterial+BMP-2, and control group: synthetic bone+BMP-2. The samples taken from these defects after 4 and 8 weeks were analyzed histologically along with micro CT analysis. In our study, both powered and block type tooth autogenous bone graft successfully stimulated mesenchymal cells leading to endochondral ossification and bone regeneration. We observed that the powered bone graft material which is acid insoluble especially is preferable as a carrier for BMP-2.

中文翻译：

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在兔颅骨缺损中使用含 BMP-2 的牙齿生物材料进行骨再生的显微计算机断层扫描和组织学研究

我们的研究旨在分析粉末状和块状自体骨移植物连同骨形态发生蛋白 (BMP-2) 与合成骨移植物相比的骨诱导作用。在每只兔子的颅骨中制作三个圆形双皮质缺损，随机分为以下三组：粉状牙生物材料+BMP-2，块牙生物材料+BMP-2，对照组：合成骨+BMP-2。在 4 周和 8 周后从这些缺陷中取出的样本与显微 CT 分析一​​起进行组织学分析。在我们的研究中，动力和块状牙齿自体骨移植成功刺激了间充质细胞，导致软骨内骨化和骨再生。我们观察到，酸不溶性粉状骨移植材料特别优选作为 BMP-2 的载体。