A few reports suggest that molecular mimicry can have a role in determining the more severe and deadly forms of COVID-19, inducing endothelial damage, disseminated intravascular coagulation, and multiorgan failure. Heat shock proteins/molecular chaperones can be involved in these molecular mimicry phenomena. However, tumor cells can display on their surface heat shock proteins/molecular chaperones that are mimicked by SARS-CoV-2 molecules (including the Spike protein), similarly to what happens in other bacterial or viral infections. Since molecular mimicry between SARS-CoV-2 and tumoral proteins can elicit an immune reaction in which antibodies or cytotoxic cells produced against the virus cross-react with the tumor cells, we want to prompt clinical studies to evaluate the impact of SARS-CoV-2 infection on prognosis and follow up of various forms of tumors. These topics, including a brief historical overview, are discussed in this paper.

一些报告表明，分子拟态可以在确定更严重和致命的 COVID-19 形式、诱导内皮损伤、弥散性血管内凝血和多器官衰竭方面发挥作用。热休克蛋白/分子伴侣可能参与这些分子拟态现象。然而，肿瘤细胞可以在其表面展示由 SARS-CoV-2 分子（包括刺突蛋白）模仿的热休克蛋白/分子伴侣，类似于其他细菌或病毒感染中发生的情况。由于 SARS-CoV-2 和肿瘤蛋白之间的分子模拟可以引发免疫反应，其中针对病毒产生的抗体或细胞毒性细胞与肿瘤细胞发生交叉反应，因此我们希望推动临床研究来评估 SARS-CoV-2 的影响。 2感染对各种肿瘤的预后和随访的影响。本文讨论了这些主题，包括简要的历史概述。