Non-invasive determination of the optical properties is essential for understanding the light propagation in biological tissues and developing optical techniques for quality detection. Simulation-based models provide flexibility in designing the search space, while measurement-based models can incorporate the unknown system responses. However, the interoperability between these two types of models is typically poor. In this research, the mismatches between measurements and simulations were explored by studying the influences from light source and the incident and detection angle on the diffuse reflectance profiles. After reducing the mismatches caused by the factors mentioned above, the simulated diffuse reflectance profiles matched well with the measurements, with R² values above 0.99. Successively, metamodels linking the optical properties with the diffuse reflectance profiles were respectively built based on the measured and simulated profiles. The prediction performance of these metamodels was comparable, both obtaining R² values above 0.96. Proper correction for these sources of mismatches between measurements and simulations thus allows to build a simulation-based metamodel with a wide range of desired optical properties that is applicable to different measurement configurations.

中文翻译：

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弥合基于测量的模型和基于仿真的元模型之间的差距，以便从空间分辨的反射率分布图中导出体光学特性：照明和检测几何形状的影响

光学特性的非侵入式确定对于理解生物组织中的光传播以及开发用于质量检测的光学技术至关重要。基于仿真的模型提供了设计搜索空间的灵活性，而基于测量的模型可以合并未知的系统响应。但是，这两种类型的模型之间的互操作性通常很差。在这项研究中，通过研究光源以及入射角和检测角对漫反射率分布图的影响，探索了测量和模拟之间的不匹配。在减少了由上述因素引起的失配之后，模拟的漫反射曲线与测量值匹配得很好，R ²值大于0.99。随后，基于所测得的和模拟的轮廓分别建立了将光学特性与漫反射率轮廓联系起来的元模型。这些元模型的预测性能是可比较的，都获得了高于0.96的R ²值。因此，对测量和模拟之间不匹配的这些来源的正确校正可以构建具有广泛范围的所需光学特性的基于模拟的元模型，该模型适用于不同的测量配置。