Hypertrophic Preconditioning Attenuates Myocardial Ischaemia-Reperfusion Injury by Modulating SIRT3-SOD2-mROS-Dependent Autophagy,Cell Proliferation

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Hypertrophic Preconditioning Attenuates Myocardial Ischaemia-Reperfusion Injury by Modulating SIRT3-SOD2-mROS-Dependent Autophagy
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-05-11 , DOI: 10.1111/cpr.13051
Lei-Lei Ma _{1,

2,

3} , Fei-Juan Kong ₄ , Zheng Dong _{1,

2,

3} , Kai-Yue Xin ₅ , Xing-Xu Wang _{1,

2,

3} , Ai-Jun Sun _{1,

2,

3} , Yun-Zeng Zou _{1,

2,

3} , Jun-Bo Ge _{1,

2,

3}

Affiliation

Ischaemic preconditioning elicited by brief periods of coronary occlusion and reperfusion protects the heart from a subsequent prolonged ischaemic insult. Here, we test the hypothesis that short-term non-ischaemic stimulation of hypertrophy renders the heart resistant to subsequent ischaemic injury.

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