Immunological memory is a fundamental hallmark of the adaptive immune responses and one of the most relevant aspects of protective immunity. Our understanding of the processes of memory T-cell differentiation and maintenance of long-term immunity is continuously evolving, and recent advances highlight new regulatory networks and chromatin dynamic changes contributing to maintain T-cell identity and impeding the reprogramming of specific T-cell states. Here, the current understanding of the mechanisms that generate the diversity and the heterogeneity of CD8⁺ T-cell subsets will be discussed, focusing on the temporal and epigenetic mechanisms orchestrating the establishment and maintenance of distinct states of T-cell fate determination and functional commitment.

中文翻译：

---

CD8+ T 细胞记忆分化过程中可塑性和命运决定的时间和表观遗传控制


免疫记忆是适应性免疫反应的基本标志，也是保护性免疫最相关的方面之一。我们对记忆 T 细胞分化和维持长期免疫过程的理解不断发展，最近的进展凸显了新的调控网络和染色质动态变化有助于维持 T 细胞身份并阻碍特定 T 细胞状态的重新编程。这里，目前对CD8多样性和异质性产生机制的理解⁺将讨论 T 细胞亚群，重点关注协调 T 细胞命运决定和功能承诺的不同状态的建立和维持的时间和表观遗传机制。