Kang et al. (1) investigate the relations between the cytokine release syndrome (CRS), cytokines, and different acute diseases that cause CRS. Their study finds strikingly elevated levels of four proinflammatory cytokines, including IL-6, IL-8, IL-10, and MCP-1, in 91 patients with CRS associated with sepsis, acute respiratory distress syndrome (ARDS), or burns. Furthermore, the elevated levels of these cytokines are positively correlated with the increasing expression of the coagulation cascade activator plasminogen activator inhibitor-1 (PAI-1). PAI-1 is capable of causing small blood clots in blood vessels throughout the body (including pulmonary blood vessels). Importantly, the increase of PAI-1 is associated with more severe pneumonia, a common cause of death in COVID-19 patients. Finally, they find that the treatment with tocilizumab, a human …

中文翻译：

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与其他急性CRS诱导疾病相比，COVID-19诱导的IL-8，IL-10和MCP-1水平降低[生物科学]

Kang等。（1）研究细胞因子释放综合征（CRS），细胞因子与引起CRS的各种急性疾病之间的关系。他们的研究发现，在91名患有败血症，急性呼吸窘迫综合征（ARDS）或烧伤的CRS患者中，四种促炎细胞因子（包括IL-6，IL-8，IL-10和MCP-1）的水平显着升高。此外，这些细胞因子的升高水平与凝血级联激活物纤溶酶原激活物抑制剂-1（PAI-1）的表达增加呈正相关。PAI-1能够引起全身血管（包括肺血管）中的小血凝块。重要的是，PAI-1的增加与更严重的肺炎有关，这是COVID-19患者的常见死亡原因。最后，他们发现用人类托洛珠单抗治疗…