Abstract

Background

Long-term potentiation (LTP) is an important functional indicator for synaptic plasticity. Extremely low frequency electromagnetic fields (ELF-EMFs) are a physical means to regulate LTP, which induce induced currents. It is unknown whether induced current is the key factor when LTP is regulated by ELF-EMFs.

New Method: A method is proposed for calculating the current value induced by ELF-EMFs. Then, a comparison of ELF-EMFs with current on the regulation of theta-burst or high-frequency stimulation (TBS/HFS)-LTP was performed.

Results

The LTP after ELF-EMFs and μA current regulation was significantly reduced. The regulatory effect of 0.1 μA current on LTP was similar with 100 Hz/2 mT ELF-EMFs, while 0.2 μA had a stronger regulatory effect than 200 Hz/2 mT on HFS-LTP.

Comparison with Existing Methods: Most of the existing methods were used to calculate the induced current in human models, while we present a more accurate model for calculating the induced current induced by ELF-EMFs in the rat brain slices.

Conclusions

This work indicated that μA current and ELF-EMFs stimulation reduced LTP. Also, we demonstrated that the regulatory effect of ELF-EMFs on LTP is not entirely deriving from the induced current, since its magnetic mechanism might have played a certain role

中文翻译：

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ELF-EMF刺激与电流刺激对幼鼠海马SC-CA1突触LTP调节的比较

 抽象的

 背景

长时程增强（LTP）是突触可塑性的重要功能指标。极低频电磁场 (ELF-EMF) 是调节 LTP 的物理手段，LTP 会感应感应电流。目前尚不清楚感应电流是否是 ELF-EMF 调节 LTP 的关键因素。

新方法：提出了一种计算 ELF-EMF 感应电流值的方法。然后，比较了 ELF-EMF 与电流对 θ 突发或高频刺激 (TBS/HFS)-LTP 的调节。

 结果

ELF-EMF 和 μA 电流调节后的 LTP 显着降低。 0.1 μA电流对LTP的调节作用与100 Hz/2 mT ELF-EMF相似，而0.2 μA电流对HFS-LTP的调节作用强于200 Hz/2 mT。

与现有方法的比较：大多数现有方法用于计算人体模型中的感应电流，而我们提出了一种更准确的模型来计算大鼠脑切片中 ELF-EMF 感应的感应电流。

 结论

这项工作表明 μA 电流和 ELF-EMF 刺激可降低 LTP。此外，我们还证明了ELF-EMF对LTP的调节作用并不完全来自感应电流，因为其磁机制可能发挥了一定的作用