Abstract

Sema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression. However, systemic studies on the correlation between Sema4D expression and the immune infiltration or clinical outcomes in tumours are still limited. Here, we analysed the landscape of Sema4D expression and its prognostic value in the cancer genome atlas pan-cancer as well as the correlation between Sema4D and immune cell infiltration by Tumour Immune Estimation Resource and Gene Expression Profiling interactive analysis online tools. Results showed that a higher Sema4D expression was significantly correlated with a favourable overall survival in diverse solid tumours including bladder cancer (Hazards Ratio (HR)=0.68, p = .0095), kidney renal clear cell carcinoma (HR = 0.61, p = .0016), melanoma (HR = 0.58, p = 6.6e-05) and thymoma (HR = 0.1, p = .011). Interestingly, Sema4D expression has positive correlation with various tumour infiltrating immune cells and immune cell biomarkers in these tumours. These results suggest that Sema4D could be a prospective biomarker for calculating hazard ratio of tumour patients and their tumour immune infiltration levels.

摘要

Sema4D 是免疫信号素家族的成员，在免疫调节、骨吸收和神经系统中起着至关重要的作用。它还参与血管生成和肿瘤进展。然而，关于 Sema4D 表达与肿瘤免疫浸润或临床结果之间相关性的系统研究仍然有限。在这里，我们通过 Tumor Immune Estimation Resource 和 Gene Expression Profiling 交互式分析在线工具分析了 Sema4D 表达的景观及其在癌症基因组图谱泛癌中的预后价值，以及 Sema4D 与免疫细胞浸润之间的相关性。结果表明，在包括膀胱癌在内的多种实体瘤中，较高的 Sema4D 表达与良好的总体存活率显着相关（危险比 (HR)=0.68，p = .0095)、肾肾透明细胞癌 (HR = 0.61, p  = .0016)、黑色素瘤 (HR = 0.58, p  = 6.6e-05) 和胸腺瘤 (HR = 0.1, p  = .011)。有趣的是，Sema4D 表达与这些肿瘤中的各种肿瘤浸润免疫细胞和免疫细胞生物标志物呈正相关。这些结果表明，Sema4D 可能成为计算肿瘤患者风险比及其肿瘤免疫浸润水平的前瞻性生物标志物。