We investigated the expression and significance of N-terminal molecular fragments of osteocalcin (N-MID), plasminogen activator inhibitor-1 (PAI-1), and RNA-binding motif 5 (RBM5) in brain metastases of lung cancer. Totally, 156 patients with lung cancer were enrolled as the research objects, of which 120 patients without brain metastases were allocated to group A, and 36 patients with brain metastases were allocated to group B. N-MID, PAI-1, and RBM5 expressions were compared between the two groups, and their predictive value in the occurrence of brain metastasis of lung cancer was analyzed. Factors influencing the development of brain metastasis of lung cancer were explored. N-MID and PAI-1 expression in group B was higher than that in group A, and RBM5 expression in group B was lower than that in group A. Following treatment, expression patterns of all three genes were significantly reversed (all P < 0.05). N-MID and PAI-1 were independent risk factors but RBM5 was an independent protective factor for brain metastasis of lung cancer (P < 0.05). N-MID and PAI-1 were highly expressed but RBM5 was poorly expressed in patients with brain metastases of lung cancer. All three could effectively predict the occurrence of brain metastasis.

我们调查了骨钙素（N-MID），纤溶酶原激活物抑制剂-1（PAI-1）和RNA结合基序5（RBM5）在肺癌的脑转移中的表达和意义。共纳入156例肺癌患者作为研究对象，其中120例无脑转移的患者被分配到A组，而36例有脑转移的患者被分配到B组。N-MID，PAI-1和RBM5表达比较两组之间的差异，并分析其对肺癌脑转移发生的预测价值。探讨了影响肺癌脑转移发展的因素。B组的N-MID和PAI-1表达高于A组，B组的RBM5表达低于A组。P  <0.05）。N-MID和PAI-1是独立的危险因素，而RBM5是肺癌脑转移的独立保护因素（P  <0.05）。N-MID和PAI-1在肺癌脑转移患者中表达高，而RBM5表达低。这三者都可以有效地预测脑转移的发生。