Journal of Cardiovascular Translational Research ( IF 2.4 ) Pub Date : 2021-05-11 , DOI: 10.1007/s12265-021-10133-9 Jan Naar 1 , Ivo Skalský 2 , Andreas Krűger 1 , Filip Málek 1 , Kevin Van Bladel 3 , Lon S Annest 3 , Petr Moučka 1 , Tomáš Mráz 1 , Vivek Y Reddy 4 , Petr Neužil 1
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The evidence supporting surgical aneurysmectomy in ischemic heart failure is inconsistent. The aim of the study was to describe long-term effect of minimally invasive hybrid transcatheter and minithoracotomy left ventricular (LV) reconstruction in patients with ischemic cardiomyopathy. Twenty-three subjects with transmural anterior wall scarring, LV ejection fraction 15–45%, and New York Heart Association class ≥ II were intervened using Revivent TC anchoring system. LV end-systolic volume index was reduced from 73.2 ± 27 ml at baseline to 51.5 ± 22 ml after 6 months (p < 0.001), 49.9 ± 20 ml after 2 years (p < 0.001), and 56.1 ± 16 ml after 5 years (p = 0.047). NYHA class improved significantly at 5 years compared to baseline. Six-min walk test distance increased at 2 years compared to the 6-month visit. Hybrid LV reconstruction using the anchoring system provides significant and durable LV volume reduction during 5-year follow-up in preselected patients with ischemic heart failure.
Graphical abstract
中文翻译：
混合左心室重建治疗缺血性心肌病的远期效果
支持缺血性心力衰竭手术动脉瘤切除术的证据不一致。该研究的目的是描述微创混合经导管和小切口左心室 (LV) 重建对缺血性心肌病患者的长期影响。使用 Revivent TC 锚定系统对 23 名透壁前壁瘢痕、左室射血分数 15-45% 和纽约心脏协会等级 ≥ II 的受试者进行干预。LV 收缩末期容积指数从基线时的 73.2 ± 27 ml 降至 6 个月后的 51.5 ± 22 ml ( p < 0.001)，2 年后为 49.9 ± 20 ml ( p < 0.001)，5 年后为 56.1 ± 16 ml ( p= 0.047)。与基线相比，NYHA 等级在 5 年时显着提高。与 6 个月的访问相比，2 年的 6 分钟步行测试距离增加了。在预选的缺血性心力衰竭患者的 5 年随访期间，使用锚定系统的混合 LV 重建可显着且持久地减少 LV 体积。
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