Meningiomas are the most common tumors of the central nervous system. Most meningiomas are benign and occur mainly in middle-aged women. Only a few cases of meningiomas in identical twins have been reported. Cyproterone acetate (Androcur® Bayer Healthcare SAS) (CPA) is an antiandrogenic progestin used to treat female hirsutism in some countries including France. We report a case of identical twin sisters who developed multiple, atypically located meningiomas in the setting of long-term CPA use. Eighteen-month follow-up showed spontaneous decrease of meningiomas after cessation of CPA. This case illustrates CPA's ability to induce development of atypically located meningiomas that differ even between identical twins, confirms benefit of surgical abstention, and raises questions regarding security of use of CPA.

脑膜瘤是中枢神经系统最常见的肿瘤。大多数脑膜瘤是良性的，主要发生在中年女性身上。仅报告了少数同卵双胞胎脑膜瘤病例。醋酸环丙孕酮 (Androcur® Bayer Healthcare SAS) (CPA) 是一种抗雄激素孕激素，在包括法国在内的一些国家用于治疗女性多毛症。我们报告了一例同卵双胞胎姐妹在长期使用 CPA 的情况下发生了多个不典型位置的脑膜瘤。十八个月的随访显示，停止 CPA 后脑膜瘤自发减少。这个案例说明了 CPA 能够诱发不典型位置的脑膜瘤发展，即使在同卵双胞胎之间也不同，证实了手术弃权的好处，并提出了关于使用 CPA 的安全性的问题。