ABSTRACT

The present study was examined the effect of a combined treatment (sertraline and positive psychotherapy) compared to the pharmacotherapy (sertraline) alone on hopelessness and suicidal ideation of patients with major depressive disorder (MDD). Patients were 100 depressed outpatients treated with either combined treatment (n = 50) or pharmacotherapy alone (n = 50). Measures were taken multiple times over the course of treatment (at baseline, 2, and 7 months later). The results of the repeated measures ANOVAs showed that pharmacotherapy alone and combined treatment had beneficial effects with a superior effect of combined treatment on hopelessness and suicidal ideation. Our results suggest that pharmacotherapy alone may not be sufficient to protect patients with MDD from suicidal ideation, especially in the early phase of the treatment with sertraline. The present results suggest that combination of pharmacotherapy and psychotherapy could be an effective option for treating major depressive disorder in both the short and long term.

摘要

本研究检查了联合治疗（舍曲林和积极心理治疗）与单独药物治疗（舍曲林）相比对重度抑郁症（MDD）患者绝望和自杀意念的影响。患者为 100 名接受联合治疗 (n = 50) 或单独药物治疗 (n = 50) 的抑郁门诊患者。在治疗过程中（基线、2 个月和 7 个月后）多次采取措施。重复测量方差分析结果表明，单独药物治疗和联合治疗具有有益效果，联合治疗对绝望和自杀意念的效果更佳。我们的研究结果表明，单独的药物治疗可能不足以保护 MDD 患者免于自杀意念，尤其是在舍曲林治疗的早期阶段。目前的结果表明，药物疗法和心理疗法的结合可能是短期和长期治疗重度抑郁症的有效选择。