In the last decade, massive omics datasets have been generated for human brain research. It is evolving so fast that a timely update is urgently needed. In this review, we summarize the main multi-omics data resources for the human brains of both healthy controls and neuropsychiatric disorders, including schizophrenia, autism, bipolar disorder, Alzheimer’s disease, Parkinson’s disease, progressive supranuclear palsy, etc. We also review the recent development of single-cell omics in brain research, such as single-nucleus RNA-seq, single-cell ATAC-seq and spatial transcriptomics. We further investigate the integrative multi-omics analysis methods for both tissue and single-cell data. Finally, we discuss the limitations and future directions of the multi-omics study of human brain disorders.

中文翻译：

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人脑疾病多组学数据资源综述及综合分析


在过去的十年中，已经为人脑研究生成了大量的组学数据集。它的发展如此之快，迫切需要及时更新。在这篇综述中，我们总结了健康对照和神经精神疾病的人脑的主要多组学数据资源，包括精神分裂症、自闭症、双向情感障碍、阿尔茨海默病、帕金森病、进行性核上性麻痹等。我们还回顾了最近的研究脑研究中单细胞组学的发展，例如单核RNA-seq、单细胞ATAC-seq和空间转录组学。我们进一步研究了组织和单细胞数据的综合多组学分析方法。最后，我们讨论了人类大脑疾病多组学研究的局限性和未来方向。