Total Synthesis in the Trost Laboratories: Selected Milestones From the Past Twenty Years,Israel Journal of Chemistry

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Total Synthesis in the Trost Laboratories: Selected Milestones From the Past Twenty Years
Israel Journal of Chemistry ( IF 2.3 ) Pub Date : 2021-05-10 , DOI: 10.1002/ijch.202100022
Guillaume Mata ₁ , Christopher A. Kalnmals ₂

Affiliation

Since the early days of his independent career, Prof. Barry M. Trost has maintained a keen interest in complex molecule synthesis. Over the past 55 years, Trost and coworkers have reported syntheses of more than 260 natural products, pharmaceuticals, and other complex biomolecules – a truly extraordinary feat and an incredible testament to Prof. Trost's inventiveness and ingenuity. Even more remarkably, Trost generated more than half of this output – as well as some of his most daring and ambitious syntheses – in just the past twenty years. This review provides a brief summary of all total syntheses from the Trost laboratories since 2000, as well as more detailed vignettes of sixteen particularly notable campaigns, including conquests of callipeltoside A, galanthamine and three related alkaloids, agelastatin A, terpestacin, pseudolaric acid B, ushikolide A, bryostatin 16, laulimalide, aeruginosin 98B, lasonolide A, perophoramidine, leustroducsin B, des-epoxy-amphidinolide N, bulleyanaline and three related alkaloids, and bryostatin 3.

中文翻译：

Trost 实验室的全合成：过去 20 年的里程碑选择

Barry M. Trost 教授在独立职业生涯的早期就对复杂分子的合成保持着浓厚的兴趣。在过去的 55 年中，Trost 及其同事报告了 260 多种天然产物、药物和其他复杂生物分子的合成——这是一项真正非凡的壮举，也是对 Trost 教授创造力和独创性的难以置信的证明。更值得注意的是，在过去的二十年里，特罗斯特创作了一半以上的作品——以及他一些最大胆和雄心勃勃的合成作品。这篇综述简要总结了自 2000 年以来 Trost 实验室的所有总合成，以及 16 个特别值得注意的运动的更详细的小插曲，包括征服 callipeltoside A、galanthamine 和三种相关生物碱、agelastatin A、terpestacin、pseudolaric acid B、des -epoxy-amphidinolide N、bulleyanaline 和三种相关的生物碱，以及苔藓抑素 3。

更新日期：2021-05-10

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