This research work’s aim was to enhance the biocompatibility of the commercially pure titanium (cpTi-2) surface via Au-ion irradiation. Various ion dosages, i.e. 7.4×1011 (Au-11), 6.47×1012 (Au-12) and 5.53×1013 (Au-13) ions⋅cm−2, were produced by exposing the polished cpTi-2 samples to Au-ion beam at room temperature. The surface topographic features of cpTi-2 and the effects of Au-ion-implanted surfaces were examined by atomic force microscopy and XRD analysis. Open-Circuit Potential (OCP), Potentiodynamic Polarization Scans (PPS) and Electrochemical Impedance Spectroscopy (EIS) were used to compare the electrochemical behavior of the cpTi-2 and Au-ion-implanted samples in Ringer’s lactate (RL) solution at 37^∘C. The effects of Au-ion irradiation on the proliferation of mesenchymal stem cells (MSCs) were estimated during 24h and 48h of exposure. Based on the experimental results, Au-12 samples presented more positive OCP and lower corrosion rate in RL solution than the Au-11 and Au-13 samples. No significant change in the morphology of the MSCs was observed after exposure to the Au-ion-implanted samples. Similar to the controlled medium, the percentage of viability of the cells of the cells on Au-12 increased from 75% to 165% on the surface of Au-13 samples during 48h of incubation indicating the positive effects of Au-ion irradiation for biocompatibility.

中文翻译：

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通过金离子辐照对商业纯钛进行表面改性，用于生物医学应用

这项研究工作的目的是通过金离子辐照提高商业纯钛 (cpTi-2) 表面的生物相容性。各种离子剂量，即7.4×1011(Au-11),6.47×1012(Au-12) 和5.53×1013(Au-13) 离子⋅厘米-2, 是通过在室温下将抛光的 cpTi-2 样品暴露于 Au 离子束而产生的。通过原子力显微镜和XRD分析检查cpTi-2的表面形貌特征和Au离子注入表面的影响。开路电位 (OCP)、动电位极化扫描 (PPS) 和电化学阻抗谱 (EIS) 用于比较 cpTi-2 和金离子注入样品在乳酸林格 (RL) 溶液中在 37 ∘ 时的电化学^行为C. 金离子辐照对间充质干细胞 (MSCs) 增殖的影响在 24h 和 48h 的曝光。根据实验结果，与Au-11和Au-13样品相比，Au-12样品在RL溶液中呈现出更高的正OCP和更低的腐蚀速率。暴露于金离子注入样品后，MSCs 的形态没有显着变化。与受控培养基相似，Au-12 上的细胞在 48孵育 h 表明金离子辐照对生物相容性的积极影响。