Creatinine level in urine is an important biomarker for renal function diseases, such as renal failure, glomerulonephritis, and chronic nephritis. The Au@MIL-101(Fe) was prepared by in situ growth of Au nanoparticles in MIL-101(Fe) as a selective SERS substrate. The Au@MIL-101(Fe) offers the great local surface plasmon resonance (SPR) effect due to gold nanoparticles aggregation inside metal-organic frameworks. The framework structure could enrich trace target samples and drag them into SPR hot spots. The optimal Au@MIL-101(Fe) composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1μmol/L and a linear relationship is ranging from 1μmol/L to 100μmol/L.

中文翻译：

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构建用于灵敏测定尿液中肌酐的Au@Metal-organic框架

尿肌酐水平是肾功能疾病的重要生物标志物，如肾功能衰竭、肾小球肾炎和慢性肾炎。Au@MIL-101(Fe) 由原位在 MIL-101(Fe) 中生长 Au 纳米颗粒作为选择性 SERS 衬底。由于金纳米粒子聚集在金属有机框架内，Au@MIL-101(Fe) 提供了出色的局部表面等离子共振 (SPR) 效应。该框架结构可以丰富微量目标样本并将其拖入SPR热点。最佳的Au@MIL-101(Fe)复合底物用于分析尿液中的肌酐，检测限低至0.1μmol/L 和线性关系从 1μ摩尔/升到 100μ摩尔/升。