Catalysis-based chemodynamic therapy (CDT) is an emerging cancer treatment strategy which uses a Fenton-like reaction to kill tumor cells by catalyzing endogenous hydrogen peroxide (H₂O2) into a toxic hydroxyl radical (⋅OH). The performance of CDT is greatly dependent on PDT agent. Herein, mitochondria-targeting Pt nanoclusters were synthesized using cytochrome c aptamer (CytcApt) as template. The obtained CytcApt-PtNCs can produce ⋅OH by H₂O₂ under the acidic conditions. Moreover, CytcApt-PtNCs could kill 4T1 tumor cells in a pH-dependent manner, but had no side effect on normal 293T cells. Therefore, CytcApt-PtNCs possess excellent therapeutic effect and good biosafety, indicating their great potential for CDT.

中文翻译：

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用于增强化学动力学治疗的细胞色素-c 适体功能化 Pt 纳米簇

基于催化的化学动力学疗法（CDT）是一种新兴的癌症治疗策略，它利用类芬顿反应通过催化内源性过氧化氢（H ₂ O2)变成有毒的羟基自由基（⋅哦）。CDT 的性能很大程度上依赖于 PDT 代理。在此，使用细胞色素 c 适体 (CytcApt) 作为模板合成了靶向线粒体的 Pt 纳米簇。获得的 CytcApt-PtNCs 可以产生⋅OH在酸性条件下由H ₂ O _2生成。此外，CytcApt-PtNCs 可以以 pH 依赖性方式杀死 4T1 肿瘤细胞，但对正常 293T 细胞没有副作用。因此，CytcApt-PtNCs具有优异的治疗效果和良好的生物安全性，表明其在CDT方面的巨大潜力。