The aim of the present study was to determine the effect of administration of Camelina sativa oil (CO) as a source of polyunsaturated fatty acids (PUFA) on bone parameters in ovariectomized rats (OVX). Overall, 40 10-week-old healthy female Wistar rats were divided into 4 groups with 10 animals in each. Rats in the control group (SHO) were subjected to a sham operation, whereas experimental rats (OVX) were ovariectomized. After a 7-day recovery period, the SHO the rats received orally 1 mL of physiological saline for the next 6 weeks. The OVX rats received orally 1 mL of physiological saline (OVX-PhS), 5 g/kg BW (OVX-CO5), or 9 g/kg BW (OVX-CO9) of camelina oil. The use of camelina oil had a significant effect on body weight, lean mass, and fat mass. The camelina oil administration suppressed the decrease in the values of some densitometric, tomographic, and mechanical parameters of femur caused by estrogen deficiency. The CO treatment increased significantly the serum level of osteocalcin and decreased the serum level of C-terminal telopeptide of type I collagen in the OVX rats. In conclusion, camelina oil exerts a positive osteotropic effect by inhibiting ovariectomy-induced adverse changes in bones. Camelina oil supplementation can be used as an efficient method for improving bone health in a disturbed state. However, further research must be carried out on other animal species supplemented with the oil.

中文翻译：

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补充茶花油可改善去卵巢大鼠的骨骼参数

本研究的目的是确定施用山茶的效果油（CO）作为卵巢切除大鼠（OVX）骨骼参数上多不饱和脂肪酸（PUFA）的来源。总体上，将40只10周龄的健康Wistar雌性大鼠分为4组，每组10只。对照组（SHO）中的大鼠接受了假手术，而实验大鼠（OVX）则被切除了卵巢。在7天的恢复期后，SHO大鼠在接下来的6周内口服1 mL生理盐水。OVX大鼠口服1 mL生理盐水（OVX-PhS），5 g / kg体重（OVX-CO5）或9 g / kg BW（OVX-CO9）的山茶油。使用山茶花油对体重，瘦肉和脂肪量有显着影响。给予山茶油抑制了雌激素缺乏引起的一些股骨密度，断层扫描和力学参数值的降低。在OVX大鼠中，CO处理显着增加了骨钙素的血清水平，并降低了I型胶原的C末端端肽的血清水平。总之，山茶花油通过抑制卵巢切除术引起的骨骼不良变化而发挥积极的促骨作用。茶花油补充剂可以用作改善处于混乱状态的骨骼健康的有效方法。但是，必须对补充了这种油的其他动物种类进行进一步的研究。茶花油补充剂可以用作改善处于混乱状态的骨骼健康的有效方法。但是，必须对补充了这种油的其他动物种类进行进一步的研究。茶花油补充剂可以用作改善处于混乱状态的骨骼健康的有效方法。但是，必须对补充了这种油的其他动物种类进行进一步的研究。