Human exposure to polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides (OPPs) by dermal route is a continuing concern in environmental and occupational toxicology. Diverse authors have measured in vitro the absorption flux and permeability coefficient (k_P) of those compounds delivered on skin surface using volatile solvents. However, there isn’t a harmonized method to obtain k_P when the test substance is deposited on the skin as a solid. Consequently, varied experimental k_Ps have been reported for PAHs and OPPs, most in clear disagreement with the values predicted by well-established mathematical models. In this work, we collected the permeation fluxes reported for these toxicants through human skin and calculated the (aqueous) k_Ps using a method based on the maximum flux and water solubility. The reanalyzed fluxes and recalculated k_Ps show improved consistency between the different experimental works and mathematical models. Notably, the recalculated k_P of benzo[a]pyrene, among others, was approximately 100 times higher than it had been previously considered. Suggestions are given to generalize the method in studies with other solvent-deposited toxicants and drugs.

人类通过皮肤途径接触多环芳烃 (PAH) 和有机磷农药 (OPP) 是环境和职业毒理学中持续关注的问题。不同的作者在体外测量了使用挥发性溶剂在皮肤表面递送的这些化合物的吸收通量和渗透系数 ( k _P )。然而，当测试物质作为固体沉积在皮肤上时，没有统一的方法来获得k _P。因此，不同的实验k _PPAH 和 OPP 的 s 已报告，大多数与完善的数学模型预测的值明显不同。在这项工作中，我们收集了这些有毒物质通过人体皮肤报告的渗透通量，并使用基于最大通量和水溶性的方法计算了（水性）k _P s。重新分析的通量和重新计算的k _P s 表明不同实验工作和数学模型之间的一致性得到改善。值得注意的是，重新计算的苯并 [a] 芘等k _P比之前考虑的高约 100 倍。建议将该方法推广到其他溶剂沉积毒物和药物的研究中。